For the 4.1, you'll simply disable the center channel. For the 2.1, disable the center and surrounds. You will not hook anything up to the center/sub or surround outputs.
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The ProMedia™ 4.1 personal audio system is a five-piece, THX®-Certified, high output set of speakers based on our ground-breaking ProMedia v.2-400 surround sound design. The new ProMedia™ 4.1 maximizes audio signals from PC and Macintosh computers; MP3, CD, Minidisc and DVD players; video game consoles; and even digital video cameras, VCRs and televisions; providing a fun, involving listening experience.